Probability of getting 1 Question from this chapter	70%
Ease of Revision	6.26 / 10

In Basics of Amino acids, questions can be asked from

• Chemical quirks of AA
• Tests to identify AA
• Classification of AA

In Metabolism of Amino acids, questions have been asked from

• Amino Acid Derivatives
• Vitamins involved AA metabolism
• Biological Amines
• AA & TCA Cycle

Lastly, in errors of AA metabolism, focus on the following

• AA disorders and defective enzymes
• Characteristic odor in different conditions
• Biochemical defect in different conditions
• Lab & Clinical Findings in different conditions

Blindly read Amino acids in Harper and you are probably assured 12 marks.

Questions on this chapter from recent NEET and AIIMS examinations have been about

• Cystinuria – Lab findings

  • Cystinuria – Cystine is excreted in Urine
  • Due to defective reabsorption in Proximal Convoluted tubule
  • Affects 4 AA:
    • Cystine
    • Ornithine
    • Arginine
    • Lysine
  • Autosomal recessive inheritance
  • Cyanide–nitroprusside test – helps detect elevated cystine in Urine
  • Rx – Hydration, Alkalinisation, Penicillamine
• Amino Acid Derivatives
• Primary hyperoxaluria – Defect
• Imino-ring AA
• Ninhydrin test is used to detect
• Basic Amino acids

  • Basic AA
  • HAL is a basic aeronautical company
    • Histidine
    • Arginine
    • Lysine
  • Acidic AA
  • Attorney General (AG) has an acidic tongue
    • Aspartate
    • Glutamate
• Gyrate atrophy of retina and choroid – Defect
• Tetrahydrobiopterin is a coenzyme for
• Rate-limiting enzyme in the biosynthesis of catecholamines
• Type 1 Tyrosinemia
• FIGLU is an intermediate in
• Amino acids absorb UV light due to
• Characteristics of the titration curve
• Phenylketonuria – Clinical Features, Lab findings
• Maple Syrup Urine Disease – Defect
• Ketogenic AA
• Alkaptonuria – Clinical features, Defect, Lab findings
• Precursor AA for Urea & Nitric oxide
• Enzyme involved in Oxidative deamination
• AA associated with Post-translational modification
• Phenylalanine is the precursor of
• Tyrosinemia & Enzymes
• Sem-essential AA
• Carcinoid syndrome – Biochemistry
• Xanthurenic aciduria – Enzyme
• AA and UV light
• AA used in Norepinephrine to epinephrine conversion
• Metabolic derivative of tryptophan
• Tests to Identify Specific Amino Acids
• Fish odor syndrome – Defect
• Wilson disease – Lab findings
• Identify Branched-chain AA
• Responsible for the negative charge in fibrinopeptide A
• Essential AA

 

Some of the questions that can come in the said topics are

• Most sterically flexible AA
• Sanger’s reagent
• AA undergoing transamination
• Cahill and Cori cycle
• AA at isoelectric pH
• Beta-alanine
• Tyrosinemias – List
• Pauly’s test
• Aromatic AA
• AA & TCA Cycle
• Homocystinuria
• AA acting as physiological buffer
• AA not encoded by genetic code
• Amino Acids and their Special structures
• Sakaguchi test
• Classification of AA – Based on structure, polarity, metabolism, source
• Glycine derivatives
• Histidine derivatives
• Hartnup’s disease