Molecular basis of Cancer
|Probability of getting 1 Question from this chapter||109%|
You can easily score 4 marks from this classical Chapter on the genetic mechanisms of Carcinogenesis.
This Chapter is absolutely easy to score from.
It involves the beautiful concepts of Oncogene activation and Tumor suppressor gene disabling.
Just read about the genes involved in classical Cancer syndromes, and you are good to go. Brush up your p53,Rb and Tyrosine kinases before exam.
- p53 – Overview
- Types of RAS oncogenes
- Metastasis oncogenes
- Rb – Molecular basis
- Mutations in Cowden syndrome
- Mutations in Lobular CA Breast
- Mechanisms of Oncogene activation
- RET proto-oncogene – Associated tumor
- two-hit hypotheses proposed by
- Mutations in Uveal Melanoma
- Angiogenetic promoters in tumor cells
- BRCA – Associated tumors
- Mutations in MEN syndrome
- Gorlin syndrome – Mutation
- Mutations in Glioma
- Myc gene – Overview
- Mutations in Neurobalstoma
- Receptor & non-receptor tyrosine kinase
- Cyclins and CDKs in Oncogenesis